Advances in cellular resolution microscopy for brain imaging in rats
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Date
2023-10
Authors
Kim, Su Jin
Affan, Rifqi O.
Frostig, Hadas
Scott, Benjamin B.
Alexander, Andrew S.
Version
Published version
OA Version
Citation
S.J. Kim, R.O. Affan, H. Frostig, B.B. Scott, A.S. Alexander. 2023. "Advances in cellular resolution microscopy for brain imaging in rats." Neurophotonics, Volume 10, Issue 4, pp.044304-. https://doi.org/10.1117/1.NPh.10.4.044304
Abstract
Rats are used in neuroscience research because of their physiological similarities with humans and accessibility as model organisms, trainability, and behavioral repertoire. In particular, rats perform a wide range of sophisticated social, cognitive, motor, and learning behaviors within the contexts of both naturalistic and laboratory environments. Further progress in neuroscience can be facilitated by using advanced imaging methods to measure the complex neural and physiological processes during behavior in rats. However, compared with the mouse, the rat nervous system offers a set of challenges, such as larger brain size, decreased neuron density, and difficulty with head restraint. Here, we review recent advances in in vivo imaging techniques in rats with a special focus on open-source solutions for calcium imaging. Finally, we provide suggestions for both users and developers of in vivo imaging systems for rats.
Description
License
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.NPh.10.4.044304]