Characterization of tuberculosis-affiliated immune correlates of protection in an immunocompetent susceptible mouse model
OA Version
Citation
Abstract
Roughly 25% of the global population is estimated to harbor a latent tuberculosis infection at any given time. For reasons currently largely unknown, 10% of primary lesions caused by this infection reactivate and progress to the contagious form of post-primary pulmonary tuberculosis (pppTB). pppTB causes 1.5 million deaths annually, making it second to COVID-19 for most-lethal by volume disease in recent years. Humans are the only known reservoir of infection, making complete eradication a possibility. The BCG tuberculosis vaccine is administered to 100 million children annually, but does not confer lifelong immunity, rather it prevents progression from primary infection to pppTB. We aimed to investigate lesional immune cell population differences in BCG–vaccinated Kramnik mice, which faithfully recapitulate human-like pppTB pathogenesis. We found that low-titer vaccination is more similar to not being vaccinated at all than it is to adequately high-dosage vaccination via multiplex fluorescent immunohistochemistry to characterize myeloid and lymphocyte subpopulations within pulmonary lesions.
Description
2024
License
Attribution 4.0 International