Sialic acids: their in vitro and in vivo inhibitation of antibody-antigen agglutinogen reactions
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Abstract
The in vitro relationship of sialic acids to the A, B, M, N, C, D, and E antigens of the human erythrocyte has been studied by means of the Landsteiner hapten inhibition test with the idea that substances that strongly inhibit anti-D might find practical application in the prevention and treatment of erythroblastosis fetalis. Our results suggest that N-acetyl neuraminic acid (NANA) is a major constituent of the D (Rh0), M, and N agglutinogens, a minor constituent of the A antigen, but is probably not a functional portion of the B, C, and E antigenic structures. [TRUNCATED]
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Thesis (Ph.D.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.