Diphenylhydantoxin hyperplasia of human gingiva : a review of the literature
Date
1978
DOI
Authors
Baylin, Steven Michael
Version
OA Version
Citation
Abstract
Diphenylhydantoin gingival hyperplasia is one of the pathological side effects observed during the course of anticonvulsant drug therapy with diphenylhydantoin (phenytoin; Dilantin sodium; sodium diphenylhydantoinate). It is a drug derived from a base known as glycolyl urea, or allantoin, a secretion of insect larvae called maggots.
Dilantin was the product of a planned search for new chemicals capable of suppressing electroshock convulsions in laboratory animals by raising the threshold, [15] and since its introduction as the symptomatic treatment modality of epilepsy by Merritt and Putman in 1938, [2] has remained the drug of choice for Grand Mal, focal and psycho-motor epilepsy, but not absence (Petit Mal) seizures. [7,11] Use of phenytoin for Petit Mal epilepsy, is not suggested, as it may increase the frequency of seizures. [3.6]
Many authors over the past forty years have presented in the literature the varied subject matter pertaining to diphenylhydantoin gingival hyperplasia - etiology, incidence, clinical features, histopathology, pathogenesis, differential diagnosis and treatment. It is the purpose of this study to review all the literature to date pertaining to this pathologic entity, including a background to the drug itself; that is, its pharmacological effects, absorption, distribution, excretion and other uses and side effects.
Description
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Thesis (M.Sc.D)--Boston Univeristy School of Graduate Dentistry, 1978. (Pedodontics)
Bibliography: p. 47-77.
Thesis (M.Sc.D)--Boston Univeristy School of Graduate Dentistry, 1978. (Pedodontics)
Bibliography: p. 47-77.
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This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.