CAS: Psychological and Brain Sciences: Scholarly Papers
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Item Predictors of self-perceived stigma in Parkinson’s disease(Elsevier, 2019) Salazar, Robert D.; Weizenbaum, Emma; Ellis, Terry D.; Earhart, G.M.; Ford, M.P.; Dibble, L.E.; Cronin-Golomb, AliceOBJECTIVE: The burden of PD extends beyond physical limitations and includes significant psychosocial adjustments as individuals undergo changes to their self-perception and how others perceive them. There is limited quantitative evidence of the factors that contribute to self-perceived stigma, which we addressed in the present study. METHODS: In 362 individuals with PD (157 women, 205 men), self-perceived stigma was measured by the four-item stigma subscale of the Parkinson's Disease Questionnaire (PDQ-39). Hierarchical linear modeling was used to assess predictors of stigma including demographics (age, gender) and disease characteristics: duration, stage (Hoehn & Yahr Scale), motor severity (Unified Parkinson's Disease Rating Scale, UPDRS, Part 3), activities of daily living (UPDRS Part 2), and depression (Geriatric Depression Scale). Predictor variables were chosen based on their significant correlations with the stigma subscale. Further analyses were conducted for men and women separately. RESULTS: For the total sample, the full model accounted for 14% of the variance in stigma perception (p < .001). Younger age and higher depression scores were the only significant predictors (both p < .001). This pattern was also seen for the men in the sample. For the women, only depression was a significant predictor. Depression mediated the relation between stigma and activities of daily living. CONCLUSIONS: Younger age (men) and depression (men and women) were the primary predictors of self-perceived stigma in PD. Disease characteristics (motor and ADL) did not contribute to stigma perception. Depression is a potential treatment target for self-perceived stigma in PD.Item Two-year-olds use past memories to accomplish novel goals(Elsevier BV, 2022-02) Blankenship, Tashauna L.; Kibbe, Melissa M.Memory-guided planning involves retrieving relevant memories and applying that information in service of a goal. Previous studies have shown substantial development in this ability from 3 to 4 years of age. We investigated the emergence of memory-guided planning by asking whether 2-year-olds could draw on episodic memories of past experiences to generate and execute plans. In Experiments 1 and 2 (N = 32, ds > .7), 2-year-olds successfully did so, and this ability developed significantly across the third year of life. Furthermore, in Experiment 3 (N = 19, d = 0.63), 2-year-olds successfully applied episodic memories to guide plans in a novel problem context, suggesting flexibility in this ability. Together, these results suggest that some form of memory-guided planning emerges during the third year of life and may form the cognitive basis for episodic prospection later in development.Item Spontaneously hypertensive rat substrains show differences in model traits for addiction risk and cocaine self-administration: implications for a novel rat reduced complexity cross(Elsevier BV, 2021-08-06) Kantak, Kathleen M.; Stots, Carissa; Mathieson, Elon; Bryant, Camron D.Forward genetic mapping of F2 crosses between closely related substrains of inbred rodents - referred to as a reduced complexity cross (RCC) - is a relatively new strategy for accelerating the pace of gene discovery for complex traits, such as drug addiction. RCCs to date were generated in mice, but rats are thought to be optimal for addiction genetic studies. Based on past literature, one inbred Spontaneously Hypertensive Rat substrain, SHR/NCrl, is predicted to exhibit a distinct behavioral profile as it relates to cocaine self-administration traits relative to another substrain, SHR/NHsd. Direct substrain comparisons are a necessary first step before implementing an RCC. We evaluated model traits for cocaine addiction risk and cocaine self-administration behaviors using a longitudinal within-subjects design. Impulsive-like and compulsive-like traits were greater in SHR/NCrl than SHR/NHsd, as were reactivity to sucrose reward, sensitivity to acute psychostimulant effects of cocaine, and cocaine use studied under fixed-ratio and tandem schedules of cocaine self-administration. Compulsive-like behavior correlated with the acute psychostimulant effects of cocaine, which in turn correlated with cocaine taking under the tandem schedule. Compulsive-like behavior also was the best predictor of cocaine seeking responses. Heritability estimates indicated that 22 %-40 % of the variances for the above phenotypes can be explained by additive genetic factors, providing sufficient genetic variance to conduct genetic mapping in F2 crosses of SHR/NCrl and SHR/NHsd. These results provide compelling support for using an RCC approach in SHR substrains to uncover candidate genes and variants that are of relevance to cocaine use disorders.Item Assessment of binge-like eating of unsweetened vs. sweetened chow pellets in BALB/c substrains(Frontiers Media SA, 2022) Sena, Katherine D.; Beierle, Jacob A.; Richardson, Kayla T.; Kantak, Kathleen M.; Bryant, Camron D.Binge eating disorder (BED) is defined as chronic episodes of consuming large amounts of food in less than 2 h. Binge eating disorder poses a serious public health problem, as it increases the risk of obesity, type II diabetes, and heart disease. Binge eating is a highly heritable trait; however, its genetic basis remains largely unexplored. We employed a mouse model for binge eating that focused on identifying heritable differences between inbred substrains in acute and escalated intake of sucrose-sweetened palatable food vs. unsweetened chow pellets in a limited, intermittent access paradigm. In the present study, we examined two genetically similar substrains of BALB/c mice for escalation in food consumption, incubation of craving after a no-food training period, and compulsive-like food consumption in an aversive context. BALB/cJ and BALB/cByJ mice showed comparable levels of acute and escalated consumption of palatable food across training trials. Surprisingly, BALB/cByJ mice also showed binge-like eating of the unsweetened chow pellets similar to the escalation in palatable food intake of both substrains. Finally, we replicated the well-documented decrease in anxiety-like behavior in BALB/cByJ mice in the light-dark conflict test that likely contributed to greater palatable food intake than BALB/cJ in the light arena. To summarize, BALB/cByJ mice show binge-like eating in the presence and absence of sucrose. Possible explanations for the lack of selectivity in binge-like eating across diets (e.g., novelty preference, taste) are discussed.Item Intensive cognitive-behavioral therapy for anxiety disorders in adolescents: a case study(SAGE Publications, 2022-08-23) Leyfer, Ovsanna; Hudson, Kelsey; Fenley, Alicia; Pincus, DonnaAnxiety disorders are one of the most common psychiatric conditions in youth and can contribute to impairment in social, academic, and family functioning. Cognitive-behavioral therapy (CBT) has been shown to be efficacious in treating youth anxiety disorders; however, for a multitude of reasons, fewer than 20% of adolescents with anxiety disorders receive services for anxiety-related problems. Intensive treatments, which rely on the same traditional components of CBT but are delivered over a shorter period of time or in a fewer number of sessions, may be particularly helpful for anxiety disorders and can offer a number of advantages over standard CBT. Despite emerging evidence supporting the advantages of the intensive approach, there are few established intensive treatment programs for youth with anxiety disorders. Further, no treatment to date has comprehensively targeted the entire spectrum of comorbid adolescent anxiety disorders in a combined intensive and transdiagnostic format, even though non-intensive (i.e., weekly delivered) CBT has been tested using a transdiagnostic approach. We developed an intensive, six-session intervention based on Angelosante and colleagues’ 2009 The Adolescent Panic Control Treatment with In-Vivo Exposures (Angelosante et al., 2009) and other empirically-supported treatments for youth to target all anxiety disorders in adolescents. We present a case study on an adolescent with multiple comorbid anxiety and related disorders who received intensive CBT treatment as a way to illustrate the clinical benefit and utility of an intensive, transdiagnostic approach. Findings support the acceptability and feasibility of transdiagnostic treatment of youth anxiety.Item Changes in apathy, depression, and anxiety in Parkinson's disease from before to during the COVID-19 era(MDPI AG, 2023-01-24) Kinger, Shraddha B.; Juneau, Truley; Kaplan, Rini I.; Pluim, Celina F.; Fox-Fuller, Joshua T.; Wang, Timothy; Mukadam, Nishaat; Neargarder, Sandy; Salazar, Robert D.; Cronin-Golomb, AliceApathy, depression, and anxiety are common non-motor symptoms of Parkinson's disease (PD). Tracking the changes in such symptoms over time would be valuable not only to determine their natural course during the disease, but also to establish the effects of unusual historical events interacting with the natural course. Having collected data on apathy (Apathy Scale), depression (Beck Depression Inventory-II), and anxiety (Parkinson's Anxiety Scale) in a large sample of persons with PD (PwPD) before the beginning of the COVID-19 era, we followed up with these individuals to investigate the changes in their prevalence of apathy, depression, and anxiety across two timepoints (T1 and T2). Of the original 347 participants, 111 responded and provided complete data at T2. The data collection at T1, before COVID-19, occurred between 2017-2018. The data collection at T2 occurred in 2021 and included the same measures, with the addition of the Coronavirus Impact Scale to assess the effects of the pandemic on the individual participants. Over this period, there was a significant increase in apathy, but not in depression or anxiety. Anxiety and depression, but not apathy, were correlated with the impact of COVID-19.Item Perceived stigma and quality of life in Parkinson's disease with additional health conditions(BMJ, 2022) Islam, Samia S.; Neargarder, Sandy; Kinger, Shraddha B.; Fox-Fuller, Joshua T.; Salazar, Robert D.; Cronin-Golomb, AliceBACKGROUND: Parkinson's disease (PD) is associated with perceived stigma and affects quality of life (QoL). Additional health conditions may influence these consequences of PD. AIMS: This study assessed the impact of health conditions on perceived stigma and QoL in persons with PD. We hypothesised that individuals with more health conditions would report more stigma and poorer QoL. We also examined the contributions of demographic and clinical characteristics to the correlations between health conditions and perceived stigma/QoL. METHODS: We identified 196 eligible participants from the Boston University Online Survey Study of Parkinson's Disease and examined their health history, performance on multiple stigma measures, and scores on the 39-item Parkinson's Disease Questionnaire assessing QoL. RESULTS: At least one health condition was reported by 79% of the sample, with a median of 2 and a range of 0-7 health conditions. More perceived stigma and poorer QoL were associated with thyroid disease, depression, anxiety, and the total number of health conditions. These correlations were related to younger age, less education, and earlier disease onset. Other health conditions (high blood pressure, back/leg surgery, headache, cancer/tumours, and heart disease) were not significantly correlated with stigma or QoL. CONCLUSIONS: Having more health conditions, or thyroid disease, depression, or anxiety, was associated with more perceived stigma and poorer QoL, with younger age, less education, and earlier disease onset affecting the associations. It is important to consider the burden of health conditions and how they affect persons with PD with specific clinical characteristics.Item Smartphone-based neuropsychological assessment in Parkinson's disease: feasibility, validity, and contextually driven variability in cognition(Cambridge University Press (CUP), 2022-04) Weizenbaum, Emma L.; Fulford, Daniel; Torous, John; Pinsky, Emma; Kolachalama, Vijaya B.; Cronin-Golomb, AliceOBJECTIVES: The prevalence of neurodegenerative disorders demands methods of accessible assessment that reliably captures cognition in daily life contexts. We investigated the feasibility of smartphone cognitive assessment in people with Parkinson's disease (PD), who may have cognitive impairment in addition to motor-related problems that limit attending in-person clinics. We examined how daily-life factors predicted smartphone cognitive performance and examined the convergent validity of smartphone assessment with traditional neuropsychological tests. METHODS: Twenty-seven nondemented individuals with mild-moderate PD attended one in-lab session and responded to smartphone notifications over 10 days. The smartphone app queried participants 5x/day about their location, mood, alertness, exercise, and medication state and administered mobile games of working memory and executive function. RESULTS: Response rate to prompts was high, demonstrating feasibility of the approach. Between-subject reliability was high on both cognitive games. Within-subject variability was higher for working memory than executive function. Strong convergent validity was seen between traditional tests and smartphone working memory but not executive function, reflecting the latter's ceiling effects. Participants performed better on mobile working memory tasks when at home and after recent exercise. Less self-reported daytime sleepiness and lower PD symptom burden predicted a stronger association between later time of day and higher smartphone test performance. CONCLUSIONS: These findings support feasibility and validity of repeat smartphone assessments of cognition and provide preliminary evidence of the effects of context on cognitive variability in PD. Further development of this accessible assessment method could increase sensitivity and specificity regarding daily cognitive dysfunction for PD and other clinical populations.Item Menstrual cycle length and modern living: a review(Ovid Technologies (Wolters Kluwer Health), 2021-12-01) Campbell, Lily R.; Scalise, Ariel L.; DiBenedictis, Brett T.; Mahalingaiah, ShruthiPURPOSE OF REVIEW: The aim of this review is to evaluate biological, life history, environmental, and lifestyle factors and exposures that cause variability in menstrual cycle length (MCL). RECENT FINDINGS: Recent literature has detailed a number of factors that influence MCL, with particular emphasis placed on novel environmental exposures, such as air pollution and endocrine disrupting chemicals. SUMMARY: MCL varies widely in response to intrinsic and extrinsic inputs and is a useful predictor of reproductive health and fecundability. VIDEO ABSTRACT: http://links.lww.com/COE/A28.Item Involvement of ventral pallidal vasopressin in the sex-specific regulation of opposite-sex preference in rats(Elsevier, 2020-03-01) DiBenedictis, Brett T.Item The importance of assessing and addressing mental health barriers to PrEP use during pregnancy and postpartum in sub-Saharan Africa: state of the science and research priorities(Wiley, 2022-10) Stanton, Amelia M.; O'Cleirigh, Conall; Knight, Lucia; Davey, Dvora L. Joseph; Myer, Landon; Joska, John A.; Mayer, Kenneth H.; Bekker, Linda-Gail; Psaros, ChristinaINTRODUCTION: Pregnant and postpartum women (PPW) in sub-Saharan Africa are at disproportionately high risk of HIV infection compared to non-pregnant women. When used consistently, pre-exposure prophylaxis (PrEP) can prevent HIV acquisition and transmission to the foetus or infant during these critical periods. Recent studies have demonstrated associations between mental health challenges (e.g. depression and traumatic stress associated with intimate partner violence) and decreased PrEP adherence and persistence, particularly among adolescents, younger women and women in the postpartum period. However, mental health is not currently a major focus of PrEP implementation research and programme planning for PPW. DISCUSSION: PrEP implementation programmes for PPW need to assess and address mental health barriers to consistent PrEP use to ensure effectiveness and sustainability in routine care. We highlight three key research priorities that will support PrEP adherence and persistence: (1) include mental health screening tools in PrEP implementation research with PPW, both to assess the feasibility of integrating these tools into routine antenatal and postpartum care and to ensure that limited resources are directed towards women whose symptoms may interfere most with PrEP use; (2) identify cross-cutting, transdiagnostic psychological mechanisms that affect consistent PrEP use during these periods and can realistically be targeted with intervention in resource-limited settings; and (3) develop/adapt and test interventions that target those underlying mechanisms, leveraging strategies from existing interventions that have successfully mitigated mental health barriers to antiretroviral therapy use among people with HIV. CONCLUSIONS: For PPW, implementation of PrEP should be guided by a robust understanding of the unique psychological difficulties that may act as barriers to uptake, adherence and persistence (i.e. sustained adherence over time). We strongly encourage PrEP implementation research in PPW to incorporate validated mental health screening tools and ultimately treatment in routine antenatal and postnatal care, and we stress the potential public health benefits of identifying women who face mental health barriers to PrEP use.Item Scale-invariant temporal history (SITH): optimal slicing of the past in an uncertain world(2017) Spears, Tyler A.; Jacques, Brandon G.; Howard, Marc W.; Sederberg, Per B.In both the human brain and any general artificial intelligence (AI), a representation of the past is necessary to predict the future. However, perfect storage of all experiences is not possible. One possibility, utilized in many applications, is to retain information about the past in a buffer. A limitation of this approach is that although events in the buffer are represented with perfect accuracy, the resources necessary to represent information at a particular time scale go up rapidly. Here we present a neurally-plausible, compressed, scale-free memory representation we call Scale-Invariant Temporal History (SITH). This representation covers an exponentially large period of time in the past at the cost of sacrificing temporal accuracy for events further in the past. The form of this decay is scale-invariant and can be shown to be optimal in that it is able to respond to worlds with a wide range of time scales. We demonstrate the utility of this representation in learning to play a simple video game. In this environment, SITH exhibits better learning performance than a fixed-size buffer history representation. Whereas the buffer performs well as long as the temporal dependencies can be represented within the buffer, SITH performs well over a much larger range of time scales for the same amount of resources. Finally, we discuss how the application of SITH, along with other human-inspired models of cognition, could improve reinforcement and machine learning algorithms in general.Item Neural scaling laws for an uncertain world(AMER PSYCHOLOGICAL ASSOC, 2016) Howard, M.W.; Shankar, K.H.Autonomous neural systems must efficiently process information in a wide range of novel environments which may have very different statistical properties. We consider the problem of how to optimally distribute receptors along a 1-dimensional continuum consistent with the following design principles. First, neural representations of the world should obey a neural uncertainty principle-making as few assumptions as possible about the statistical structure of the world. Second, neural representations should convey, as much as possible, equivalent information about environments with different statistics. The results of these arguments resemble the structure of the visual system and provide a natural explanation of the behavioral Weber-Fechner law, a foundational result in psychology. Because the derivation is extremely general, this suggests that similar scaling relationships should be observed not only in sensory continua, but also in neural representations of "cognitive" 1-dimensional quantities such as time or numerosity. (PsycINFO Database RecordItem Cognitive computation using neural representations of time and space in the Laplace domain(2020-03-25) Howard, Marc W.; Hasselmo, Michael E.Memory for the past makes use of a record of what happened when---a function over past time. Time cells in the hippocampus and temporal context cells in the entorhinal cortex both code for events as a function of past time, but with very different receptive fields. Time cells in the hippocampus can be understood as a compressed estimate of events as a function of the past. Temporal context cells in the entorhinal cortex can be understood as the Laplace transform of that function, respectively. Other functional cell types in the hippocampus and related regions, including border cells, place cells, trajectory coding, splitter cells, can be understood as coding for functions over space or past movements or their Laplace transforms. More abstract quantities, like distance in an abstract conceptual space or numerosity could also be mapped onto populations of neurons coding for the Laplace transform of functions over those variables. Quantitative cognitive models of memory and evidence accumulation can also be specified in this framework allowing constraints from both behavior and neurophysiology. More generally, the computational power of the Laplace domain could be important for efficiently implementing data-independent operators, which could serve as a basis for neural models of a very broad range of cognitive computations.Item A temporal record of the past with a spectrum of time constants in the monkey entorhinal cortex(Proceedings of the National Academy of Sciences, 2020-08-18) Bright, Ian M.; Meister, Miriam L.R.; Cruzado, Nathanael; Tiganj, Zoran; Buffalo, Elizabeth A.; Howard, Marc W.Episodic memory is believed to be intimately related to our experience of the passage of time. Indeed, neurons in the hippocampus and other brain regions critical to episodic memory code for the passage of time at a range of timescales. The origin of this temporal signal, however, remains unclear. Here, we examined temporal responses in the entorhinal cortex of macaque monkeys as they viewed complex images. Many neurons in the entorhinal cortex were responsive to image onset, showing large deviations from baseline firing shortly after image onset but relaxing back to baseline at different rates. This range of relaxation rates allowed for the time since image onset to be decoded on the scale of seconds. Further, these neurons carried information about image content, suggesting that neurons in the entorhinal cortex carry information about not only when an event took place but also, the identity of that event. Taken together, these findings suggest that the primate entorhinal cortex uses a spectrum of time constants to construct a temporal record of the past in support of episodic memory.Item Internally generated time in the rodent hippocampus is logarithmically compressed(eLife Sciences Publications, Ltd, 2022-10-17) Cao, Rui; Bladon, John H.; Charczynski, Stephen J.; Hasselmo, Michael E.; Howard, Marc W.The Weber-Fechner law proposes that our perceived sensory input increases with physical input on a logarithmic scale. Hippocampal 'time cells' carry a record of recent experience by firing sequentially during a circumscribed period of time after a triggering stimulus. Different cells have 'time fields' at different delays up to at least tens of seconds. Past studies suggest that time cells represent a compressed timeline by demonstrating that fewer time cells fire late in the delay and their time fields are wider. This paper asks whether the compression of time cells obeys the Weber-Fechner Law. Time cells were studied with a hierarchical Bayesian model that simultaneously accounts for the firing pattern at the trial level, cell level, and population level. This procedure allows separate estimates of the within-trial receptive field width and the across-trial variability. After isolating across-trial variability, time field width increased linearly with delay. Further, the time cell population was distributed evenly along a logarithmic time axis. These findings provide strong quantitative evidence that the neural temporal representation in rodent hippocampus is logarithmically compressed and obeys a neural Weber-Fechner Law.Item Are dogs indeed susceptible to Kanizsa’s triangle illusion?(Springer Science and Business Media LLC, 2023-03) Pepperberg, Irene M.Item Contrafreeloading in kea (Nestor notabilis) in comparison to Grey parrots (Psittacus erithacus)(Springer Nature, 2022-10-18) Smith, Gabriella E.; Bastos, Amalia P.M.; Chodorow, Martin; Taylor, Alex H.; Pepperberg, Irene M.Contrafreeloading—working to access food that could be freely obtained—is rarely exhibited and poorly understood. Based on data from Grey parrots (Psittacus erithacus), researchers proposed a correlation between contrafreeloading and play: that contrafreeloading is more likely when subjects view the task as play. We tested that hypothesis by subjecting a relatively more playful parrot species, the kea (Nestor notabilis), to the same experimental tasks. Experiment 1 presented eight kea with container pairs holding more- or less-preferred free or enclosed food items, and examined three types of contrafreeloading: calculated (working to access preferred food over less-preferred, freely available food); classic (working to access food identical to freely available food); and super (working to access less-preferred food over preferred, freely available food). At the group level, the kea behaved similarly to the Greys: They significantly preferred calculated contrafreeloading, performed classic contrafreeloading at chance, and significantly failed to super contrafreeload. However, overall kea engaged in more contrafreeloading than Greys. Experiment 2 examined a potentially more ecologically relevant task, a choice between shelled and unshelled walnuts. No kea contrafreeloaded for nuts, whereas two of five Greys significantly preferred nut contrafreeloading and one chose at chance. We examine proximate and adaptive explanations for the performances of these differentially playful parrot species to further elucidate the role of play in contrafreeloading.Item Hippocampal cells segregate positive and negative engrams(Springer Science and Business Media LLC, 2022-09-26) Shpokayte, Monika; McKissick, Olivia; Guan, Xiaonan; Yuan, Bingbing; Rahsepar, Bahar; Fernandez, Fernando R.; Ruesch, Evan; Grella, Stephanie L.; White, John A.; Liu, X. Shawn; Ramirez, SteveThe hippocampus is involved in processing a variety of mnemonic computations specifically the spatiotemporal components and emotional dimensions of contextual memory. Recent studies have demonstrated cellular heterogeneity along the hippocampal axis. The ventral hippocampus has been shown to be important in the processing of emotion and valence. Here, we combine transgenic and all-virus based activity-dependent tagging strategies to visualize multiple valence-specific engrams in the vHPC and demonstrate two partially segregated cell populations and projections that respond to appetitive and aversive experiences. Next, using RNA sequencing and DNA methylation sequencing approaches, we find that vHPC appetitive and aversive engram cells display different transcriptional programs and DNA methylation landscapes compared to a neutral engram population. Additionally, optogenetic manipulation of tagged cell bodies in vHPC is not sufficient to drive appetitive or aversive behavior in real-time place preference, stimulation of tagged vHPC terminals projecting to the amygdala and nucleus accumbens (NAc), but not the prefrontal cortex (PFC), showed the capacity drive preference and avoidance. These terminals also were able to change their capacity to drive behavior. We conclude that the vHPC contains genetically, cellularly, and behaviorally segregated populations of cells processing appetitive and aversive memory engrams.