Grignard Reaction - Synthesis of Substituted Benzoic Acids
Mulcahy, Seann P.
MetadataShow full item record
A convenient preparation of substituted benzoic acids from Grignard additions to solid carbon dioxide. Students create a library of carboxylic acids by using differentially substituted, commercially available aryl bromides, which can be used as the starting materials for a multistep synthesis. This is a modification and improvement of a very popular undergraduate organic chemistry experiment.