Femtosecond photonic viral inactivation probed using solid-state nanopores
Files
First author draft
Date
2018-09-04
Authors
Nazari, Mina
Li, Xiaoqing
Alibakhshi, Mohammad Amin
Yang, Haojie
Souza, Kathleen
Gillespie, Christopher
Gummuluru, Suryaram
Hong, Mi K.
Reinhard, Björn M.
Korolev, Kirill S.
Version
First author draft
OA Version
Citation
Mina Nazari, Xiaoqing Li, Mohammad Amin Alibakhshi, Haojie Yang, Kathleen Souza, Christopher Gillespie, Suryaram Gummuluru, Mi K Hong, Björn M Reinhard, Kirill S Korolev, Lawrence D Ziegler, Qing Zhao, Meni Wanunu, Shyamsunder Erramilli. 2018. "Femtosecond photonic viral inactivation probed using solid-state nanopores." Nano Futures, Volume 2, Issue 4, pp. 045005 - 045005. https://doi.org/10.1088/2399-1984/aadf9d
Abstract
We report on detection of virus inactivation using femtosecond laser radiation by measuring the
conductance of a solid state nanopore designed for detecting single particles. Conventional methods
of assaying for viral inactivation based on plaque forming assays require 24–48 h for bacterial growth.
Nanopore conductance measurements provide information on morphological changes at a single
virion level.We show that analysis of a time series of nanopore conductance can quantify the detection
of inactivation, requiring only a few minutes from collection to analysis. Morphological changes were
verified by dynamic light scattering. Statistical analysis maximizing the information entropy provides
a measure of the log reduction value. This work provides a rapid method for assaying viral inactivation
with femtosecond lasers using solid-state nanopores.