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dc.contributor.authorMikkelsen, Catherineen_US
dc.contributor.authorYazdanbakhsh, Arashen_US
dc.date.accessioned2020-05-04T15:01:43Z
dc.date.available2020-05-04T15:01:43Z
dc.date.issued2018
dc.identifier.citationCatherine Mikkelsen, Arash Yazdanbakhsh. 2018. "A Frontotemporal Regional Model of Post-Traumatic Stress Disorder." Journal of Vision. Vision Sciences Society. https://doi.org/10.1167/18.10.103
dc.identifier.issn1534-7362
dc.identifier.urihttps://hdl.handle.net/2144/40526
dc.description.abstractThe flashback is a phenomenon in Post-Traumatic Stress Disorder (PTSD) in which traumatic memories are replayed as a reaction to a stimulus. However, the underlying neural mechanisms for this phenomenon are still under investigation. We created a multi-layer model of visual input, entorhinal cortex, hippocampus, prefrontal cortex, basolateral amygdala, and the central nucleus of the amygdala, as a multi-area network to determine how these regions may be distinctively encoding the traumatic events that produce these replays. The current model dynamic shows that highly emotional visual stimuli can be generalized to similar stimuli, more so than events related to neutral stimuli. This result mimics electrophysiological results in the amygdala (Ghosh & Chattarji, 2015). Our network dynamics can be used to create a more nuanced approach to PTSD treatments: it could replicate outcomes of techniques such as Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) and improve the spatial and temporal configuration of the technique. Our model characterizes the spatio-temporal aspects of the flashback phenomenon and as such aids in the spatio-temporal fine-tuning of treatments such as EMDR. As a future direction, we can incorporate in the model individual and developmental differences in plasticity in responding to current treatments based on visual stimuli to come up with optimized treatment for each individual affected by PTSD.en_US
dc.language.isoen_US
dc.publisherAssociation for Research in Vision and Ophthalmologyen_US
dc.relation.ispartofJournal of Vision
dc.rights© 2018 ARVO. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.subjectExperimental psychologyen_US
dc.titleA frontotemporal regional model of Post-Traumatic Stress Disorderen_US
dc.typeConference materialsen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1167/18.10.103
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv428782


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© 2018 ARVO. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Except where otherwise noted, this item's license is described as © 2018 ARVO. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.