Recently Added

  • Eukaryotic translation initiation factor 4AI: a potential novel target in neuroblastoma 

    Skofler, Christina; Kleinegger, Florian; Krassnig, Stefanie; Birkl-Toeglhofer, Anna Maria; Singer, Georg; Till, Holger; Benesch, Martin; Cencic, Regina; Porco, John A.; Pelletier, Jerry; Castellani, Christoph; Raicht, Andrea; Izycka-Swieszewska, Ewa; Czapiewski, Piotr; Haybaeck, Johannes (2021-02-02)
    Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. Children suffering from high-risk and/or metastatic NB often show no response to therapy, and new therapeutic approaches are urgently needed. Malignant ...
  • Targeting oncoprotein translation with rocaglates in MYC-driven lymphoma 

    Zhang, Xuan; Bi, Chengfeng; Lu, Ting; Yue, Ting; Zhang, Weiwei; Zhang, Xiaoyan; Cheng, Wang; Tian, Tian; Lunning, Matthew A.; Vose, Julie M.; Pelletier, J.; Porco, John A.; Tao, J.; Fu, Kai (AMER SOC HEMATOLOGY, 2018-11-29)
    MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy and high risk of ...
  • A forward genetic screen identifies modifiers of rocaglate responsiveness 

    Shen, Leo; Pugsley, Lauren; Cencic, Regina; Wang, HanChen; Robert, Francis; Naineni, Sai Kiran; Sahni, Ananya; Morin, Genevieve; Zhang, Wenhan; Nijnik, Anastasia; Porco, John A.; Langlais, David; Huang, Sidong; Pelletier, Jerry (2021-09-16)
    Rocaglates are a class of eukaryotic translation initiation inhibitors that are being explored as chemotherapeutic agents. They function by targeting eukaryotic initiation factor (eIF) 4A, an RNA helicase critical for ...
  • Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis 

    Chatterjee, Sujoy; Yabaji, Shivraj M.; Rukhlenko, Oleksii S.; Bhattacharya, Bidisha; Waligurski, Emily; Vallavoju, Nandini; Ray, Somak; Kholodenko, Boris N.; Brown, Lauren E.; Beeler, Aaron B.; Ivanov, Alexander R.; Kobzik, Lester; Porco, John A.; Kramnik, Igor (2021-08-20)
    Macrophages contribute to host immunity and tissue homeostasis via alternative activation programs. M1-like macrophages control intracellular bacterial pathogens and tumor progression. In contrast, M2-like macrophages shape ...
  • Synthesis and multiplexed activity profiling of synthetic acylphloroglucinol scaffolds 

    Boyce, Jonathan H.; Reisman, Benjamin J.; Bachmann, Brian O.; Porco, John A. (2021-01-18)
    Reported here are novel formic-acid-mediated rearrangements of dearomatized acylphloroglucinols to access a structurally diverse group of synthetic acylphloroglucinol scaffolds (SASs). Density-functional theory (DFT) ...
  • Coumarin bromination 

    Loy, Rebecca (2022)
    In this open ended experiment, students have to determine the identity of the brominated product when a coumarin is treated with N-bromosuccinimide (NBS). The product is purified via column chromatography and analyzed by ...
  • Friedel-Crafts acylation 

    Loy, Rebecca (2022)
    A Friedel-Crafts acylation of anisole with maleic anhydride promoted by aluminum chloride. The reaction goes at room temperature in 30 minutes and the product can be purified via recrystallization. The final product can ...
  • Passerini reaction 

    Loy, Rebecca (2022)
    A simple Passerini reaction using acetic acid, benzaldehyde and methyl isocyanoacetate, that is is complete in 40 minutes. The product can be purified via recrystallization. Students can analyze the product using NMR, IR ...
  • Pechmann condensation 

    Loy, Rebecca (2022)
    A simple preparation of a coumarin product via an Pechmann condensation catalyzed by sulfuric acid. The product can be analyzed by NMR and LC/MS. Fluorescence is examined at various pHs in water using a UV lamp.
  • Cyclization of citronellal 

    Loy, Rebecca
    A simple cyclization of citronellal catalyzed by ferric choride. Introduces students to extraction and column chromatography. Diastereomers of the product are visible by TLC and allows for a discussion of stereochemistry ...

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