Boston University’s Chemistry Department is committed to excellence in both scientific research and teaching. The department has grown significantly over the past decade in the number and quality of its faculty and in its research facilities. Chemistry offers BA, MA, and PhD degrees, and faculty participate in interdisciplinary programs and research in the Photonics Research Center; the Center for Computational Science; the Molecular Biology, Cell Biology, & Biochemistry Program; the Bioinformatics Program; the School of Medicine; and the College of Engineering.
Department chair: Lawrence Ziegler
Campus address: 590 Commonwealth Avenue, Room 299
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Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation (2018-04-04)Ovothiol is a histidine thiol derivative. The biosynthesis of ovothiol involves an extremely efficient trans-sulfuration strategy. The nonheme iron enzyme OvoA catalyzed oxidative coupling between cysteine and histidine ...
Mechanistic elucidation of two catalytically versatile iron(II)- and α-ketoglutarate-dependent enzymes: cases beyond hydroxylation (Informa UK Limited, 2018-07-04)Iron(II)- and α-ketoglutarate-dependent (Fe/αKG) enzymes catalyze a large array of reactions. Although hydroxylation reaction catalyzed by these enzymes has been investigated in great details, involving the ferryl (FeIV=O) ...
Mini-review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis (2018-06-19)As one of the most abundant elements on earth, sulfur is part of many small molecular metabolites and is key to their biological activities. Over the past few decades, some general strategies have been discovered for the ...
Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses (2018-08-15)Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical reactions, including hydroxylation, ring fragmentation, ...
(AMER CHEMICAL SOC, 2018-08-17)Eucalyptusdimers A–C, three dimeric phellandrene-derived meroterpenoids featuring an unprecedented, fused skeleton between two phellandrene and two acylphloroglucinol subunits, along with one biogenetically related ...
Evaluating the impact of fluorination on the electro-optical properties of cross-conjugated benzobisoxazoles (AMER CHEMICAL SOC, 2019-02-21)Six 2,4,6,8-tetrarylbenzo[1,2-d:4,5-d′]bisoxazoles (BBOs) were synthesized: three bearing phenyl substituents at the 2- and 6-positions and three bearing perfluorophenyl groups at those positions. The influence of ...
Asymmetric synthesis of griffipavixanthone employing a chiral phosphoric acid-catalyzed cycloaddition (AMER CHEMICAL SOC, 2019-01-09)Asymmetric synthesis of the biologically active xanthone dimer griffipavixanthone is reported along with its absolute stereochemistry determination. Synthesis of the natural product is accomplished via dimerization of a ...
Small molecule amyloid-beta protein precursor processing modulators lower amyloid-beta peptide levels via cKit signaling (IOS PRESS, 2019-01-01)Alzheimer’s disease (AD) is characterized by the accumulation of neurotoxic amyloid-β (Aβ) peptides consisting of 39-43 amino acids, proteolytically derived fragments of the amyloid-β protein precursor (AβPP), and the ...
Isolation and synthesis of novel meroterpenoids from rhodomyrtus tomentosa: investigation of a reactive enetrione intermediate (2019-03-22)Rhodomyrtusials A-C, the first examples of triketone-sesquiterpene meroterpenoids featuring a unique 6/5/5/9/4 fused pentacyclic ring system were isolated from Rhodomyrtus tomentosa, along with several biogenetically-related ...