Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory
Date
2008-7-6
Authors
Lipton, P. A.
Eichenbaum, H.
Version
OA Version
Citation
Hasselmo, Michael E., Mark P. Brandon. "Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory" Neural Plasticity 2008:258467.
Abstract
Spatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes to spatial information processing. Here, we discuss recent electrophysiological findings that offer an alternate view of hippocampal and medial entorhinal function. These findings suggest complementary contributions of the hippocampus and medial entorhinal cortex in support of episodic memory, wherein hippocampal networks encode sequences of events that compose temporally and spatially extended episodes, whereas medial entorhinal networks disambiguate overlapping episodes by binding sequential events into distinct memories.
Description
License
Copyright 2008 P. A. Lipton and H. Eichenbaum. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.