Nanoscale field effect transistor for biomolecular signal amplification
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Published version
Date
2007-12-10
Authors
Chen, Yu
Wang, Xihua
Hong, Mi K.
Erramilli, Shyamsunder
Mohanty, Pritiraj
Rosenberg, Carol
Version
OA Version
Citation
Yu Chen, Xihua Wang, Mi K Hong, Shyamsunder Erramilli, Pritiraj Mohanty, Carol Rosenberg. 2007. "Nanoscale field effect transistor for biomolecular signal amplification." Appl. Phys. Lett. 91, 243511; https://doi.org/10.1063/1.2822445
Abstract
We report amplification of biomolecular recognition signal in lithographically defined silicon nanochannel devices. The devices are configured as field effect transistors (FET) in the reversed source-drain bias region. The measurement of the differential conductance of the nanowire channels in the FET allows sensitive detection of changes in the surface potential due to biomolecular binding. Narrower silicon channels demonstrate higher sensitivity to binding due to increased surface-to-volume ratio. The operation of the device in the negative source-drain region demonstrates signal amplification. The equivalence between protein binding and change in the surface potential is described.
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© 2007 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.