Optimal path to epigenetic switching
Files
Accepted manuscript
Date
2005-01-01
Authors
Roma, D. M.
O'Flanagan, R. A.
Ruckenstein, A. E.
Sengupta, A. M.
Mukhopadhyay, R.
Version
Accepted manuscript
OA Version
Citation
D.M. Roma, R.A. O'Flanagan, A.E. Ruckenstein, A.M. Sengupta, R. Mukhopadhyay. 2005. "Optimal path to epigenetic switching." PHYSICAL REVIEW E, Volume 71, Issue 1, pp. ? - ? (5). https://doi.org/10.1103/PhysRevE.71.011902
Abstract
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.